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MENOPAUSAL HOT FLUSHES : A DOUBLE BLIND COMPARISON OF PLACEBO, ETHINYL OESTRADIOL AND NORGESTREL
Author(s) -
Dennerstein Lorraine,
Burrows G. D.,
Hyman G.,
Wood C.
Publication year - 1978
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1978.tb15842.x
Subject(s) - progestogen , placebo , norgestrel , levonorgestrel , medicine , microgram , regimen , crossover study , triptorelin , endocrinology , population , hormone , chemistry , research methodology , luteinizing hormone , family planning , biochemistry , alternative medicine , environmental health , pathology , in vitro , gonadotropin releasing hormone
Summary A double blind crossover study was planned in order to compare the effects of oestrogen, progestogen and placebo on hot flushes. The 49 women studied had previously undergone hysterectomy and bilateral oophorectomy. The drug regimen consisted of three months each of ethinyl oestradiol 50 μg/day, d norgestrel 250 μg/day, a combination of these two substances (‘ordiol’) and a placebo. The predominant reason for requesting a change of medication was intolerable hot flushes associated with placebo use. All hormonal preparations were found to be significantly more effective than placebo in reducing hot flush frequency and intensity. Oestrogen containing medications were more effective than the progestogen (norgestrel).