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THE SIGNIFICANCE OF A LOW AMNIOTIC FLUID CREATININE AND A MATURE LECITHIN/SPHINGOMYELIN RATIO
Author(s) -
Jenkins D. T.,
Wishart M. M.
Publication year - 1978
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1978.tb10481.x
Subject(s) - amniotic fluid , creatinine , lecithin , sphingomyelin , medicine , obstetrics , renal function , pregnancy , physiology , endocrinology , chemistry , fetus , biology , cholesterol , chromatography , genetics
Summary Creatinine levels were measured in 546 specimens of amniotic fluid with a lecithin/ sphingomyelin ratio of 2.5 or more. With amniotic fluid creatinine levels below the normal range, 3 of 6 infants had major congenital abnormalities and two had severe rhesus isoimmunization; 3 of the infants died. Of 514 cases with amniotic fluid creatinine levels within the normal range (mean±2 SD), 13 babies (2.5 per cent) had major congenital abnormalities but only one of the babies died, giving a perinatal mortality rate of 0.2 per cent. The significance of these findings is discussed.