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METABOLIC EFFECTS OF BETA‐SYMPATHOMIMETIC DRUGS AND DEXAMETHASONE IN NORMAL AND DIABETIC PREGNANCY
Author(s) -
Borberg C.,
Gillmer M. D. G.,
Beard R. W.,
Oakley N. W.
Publication year - 1978
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1978.tb10478.x
Subject(s) - dexamethasone , medicine , endocrinology , diabetic ketoacidosis , insulin , diabetes mellitus , beta (programming language) , drug , pharmacology , computer science , programming language
Summary Marked hyperglycaemia and hyperinsulinaemia were observed in two normal women in premature labour treated with an intravenous infusion of a β‐sympathomimetic drug and intramuscular dexamethasone injections. Similar therapy in a chemical diabetic patient caused diabetic ketoacidosis, while treatment of an insulin dependent diabetic with dexamethasone alone resulted in a major increase in her insulin requirements. It is suggested that the diabetogenic effects of β‐sympathomimetic drugs and dexamethasone may be additive and that regular plasma glucose estimations should be made when they are used, especially in patients with impaired glucose tolerance.