Premium
THE EFFECT OF PREGNANCY AND TWO DIFFERENT CONTRACEPTIVE PILLS ON SERUM LIPIDS AND LIPOPROTEINS IN A WOMAN WITH A TYPE III HYPERLIPOPROTEINAEMIA PATTERN
Author(s) -
Muller D. P. R.,
Pavlou C.,
Whitelaw A. G. L.,
McLintock D.
Publication year - 1978
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1978.tb10466.x
Subject(s) - pill , pregnancy , blood lipids , endocrinology , medicine , physiology , cholesterol , obstetrics , biology , pharmacology , genetics
Summary We report a woman who had a moderate elevation of serum triglycerides with a type III pattern of hyperlipoproteinaemia when taking a normal diet. She developed eruptive xanthomata with a grossly raised serum triglyceride concentration and chylomicronaemia when pregnant and also when taking a combined oral contraceptive pill containing 50 μg of oestrogen. The xanthomata cleared and the triglyceride level fell when the combined oral contraceptive pill was changed to one with a lower oestrogen content, clofibrate was prescribed and the diet was restricted in carbohydrate and fat. Persistent chylomicronaemia is a serious complication of pregnancy because of the risk of pancreatitis and the potential risk of fetal malnutrition. Treatment with diet and clofibrate is indicated. High oestrogen‐containing contraceptive pills appear to be contraindicated in patients with type III or other hypertriglyceridaemic states.