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BLOOD COAGULATION STUDIES IN PREGNANT PATIENTS WITH INFECTIVE HEPATITIS
Author(s) -
Dube B.,
Bhattacharya Sulekha,
Sinha V. N.,
Pandey L. K.,
Dube R. K.
Publication year - 1977
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1977.tb12660.x
Subject(s) - medicine , prothrombin time , coagulopathy , fibrinogen , coagulation , fibrinolysis , disseminated intravascular coagulation , liver failure , thrombin time , clotting factor , hepatitis , gastroenterology , coagulation disorder , heart failure , coagulation testing , bleeding diathesis , pregnancy , partial thromboplastin time , platelet , genetics , biology
Summary Coagulation studies were made on 22 pregnant women with acute infective hepatitis and on 15 normal control pregnant women in third trimester. Fourteen hapatitis patients had clinical evidence of liver failure and all of them had a haemorrhagic diathesis; none of the patients without liver failure showed clinical evidence of haemostatic defects. Coagulopathy was present in most patients, its severity being greater in those with hepatic failure. Significant alterations were observed in bleeding time, whole blood clotting time, prothrombin time, thrombin time, plasma fibrinogen and serum levels of fibrinogen degradation products. The last three disturbances were most frequent in patients with liver failure. Increased fibrinolysis and disseminated intravascular coagulation also appeared to play a contributory role, particularly in patients with hepatic failure.