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INCREASE OF THE PROSTAGLANDIN PRECURSOR, ARACHIDONIC ACID, IN AMNIOTIC FLUID DURING SPONTANEOUS LABOUR
Author(s) -
Keirse M. J. N. C.,
Hicks B. R.,
Mitchell M. D.,
Turnbull A. C.
Publication year - 1977
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1977.tb12524.x
Subject(s) - arachidonic acid , prostaglandin , amniotic fluid , prostaglandins f , chemistry , medicine , endocrinology , biosynthesis , prostaglandin e , biochemistry , biology , pregnancy , fetus , enzyme , genetics
Summary Concentrations of free arachidonic acid have been measured by gas liquid chromatography in amniotic fluid obtained during spontaneous labour at term. Levels of arachidonic acid ranged from 0·14 to 2·2 μg/ml and increased significantly (P<0·01) with advancing cervical dilatation. Concentrations of arachidonic acid showed no significant relation to concentrations of either prostaglandin F or 13,14‐dihydro‐15‐keto‐prostaglandin F. These findings are discussed with respect to the role of arachidonic acid in the control of prostaglandin biosynthesis during human parturition.