Premium
FACTOR VIII‐RELATED ANTIGEN AND FACTOR VIII COAGULANT ACTIVITY IN NORMAL AND PRE‐ECLAMPTIC PREGNANCY
Author(s) -
Thornton C. A.,
Bonnar J.
Publication year - 1977
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1977.tb12521.x
Subject(s) - eclampsia , medicine , pregnancy , antigen , risk factor , fetus , obstetrics , endocrinology , immunology , biology , genetics
Summary The changes in the ratio between factor VIII‐related antigen and factor VIII activity were compared in ten patients with normal pregnancies and in ten patients with severe pre‐eclampsia. In the patients with pre‐eclampsia, a highly significant increase in the ratio was observed during the third trimester. No difference in the ratio between the two groups was found on day 7 of the puerperium. In the pre‐eclamptic patients, the highest ratios for factor VIII‐related antigen to factor VIII activity were associated with either a perinatal death or with the delivery of a severely growth retarded infant. These findings are in keeping with an increased rate of thrombin production in women with pre‐eclampsia, and suggest that the ratio of factor VIII‐related antigen to factor VIII activity may reflect the severity of the effect of the disease process on the fetus.