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EFFECT OF HORMONE REPLACEMENT THERAPY ON GLUCOSE TOLERANCE IN POSTMENOPAUSAL WOMEN
Author(s) -
Thom Margaret,
Chakravarti S.,
Oram D. H.,
Studd J. W. W.
Publication year - 1977
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1977.tb12492.x
Subject(s) - estradiol valerate , microgram , medicine , mestranol , hormone replacement therapy (female to male) , postmenopausal women , endocrinology , hormone therapy , glucose tolerance test , estrogen therapy , hormone , estrogen , physiology , population , biology , research methodology , insulin , cancer , biochemistry , insulin resistance , in vitro , breast cancer , testosterone (patch) , family planning , environmental health
Summary Oral glucose tolerance tests were performed on 50 symptomatic postmenopausal women before and after three months of hormone replacement therapy. All patients were randomly allocated to one of five groups treated with various synthetic or so‐called naturally occurring oestrogens. Therapy produced a significant deterioration of carbohydrate tolerance with sequential preparations containing 100 μg of ethinyl oestradiol or graduated doses of mestranol up to 50 μg. The conjugated equine oestrogen (1·25 mg daily) and oestrogen valerate (2 mg daily) treated groups did not show abnormal glucose tolerance. The decreased glucose tolerance may be due as much to dosage levels as to any metabolic characteristics of the various oestrogens prescribed.