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CIRCULATING LEVELS OF PREGNANCY‐SPECIFIC β 1 ‐GLYCOPROTEIN IN EARLY PREGNANCY
Author(s) -
Grudzinskas J. G.,
Lenton E. A.,
Gordon Y. B.,
KELSO I. M.,
Jeffrey D.,
Sobowale O.,
Chard T.
Publication year - 1977
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1977.tb12483.x
Subject(s) - ovulation , pregnancy , luteinizing hormone , bromocriptine , medicine , endocrinology , human chorionic gonadotropin , hormone , andrology , biology , prolactin , genetics
Summary Circulating levels of pregnancy‐specific β 1 ‐glycoprotein (SP 1 or PSβG), luteinizing hormone (LH) and human chorionic gonadotrophin (HCG) were measured serially in 9 subjects immediately after conception. Ovulation occurred spontaneously in 3 subjects, or followed administration of clomiphene citrate (2 subjects) or bromocriptine (4 subjects). The timing of ovulation was determined by the appearance of the LH surge. Levels of HCG were detected 10 to 16 days, and SP 1 , 18 to 23 days after ovulation. These findings suggest that the measurement of plasma levels of SP 1 may provide valuable additional biochemical evidence of pregnancy.