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SELECTIVE INHIBITION BY DANAZOL OF FOLLICLE STIMULATING HORMONE DURING THE LUTEAL PHASE
Author(s) -
Lieberman B. A.,
Thom S.,
Murray M. A. F.,
Jacobs H. S.
Publication year - 1977
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1977.tb12468.x
Subject(s) - luteinizing hormone , luteal phase , ovulation , endocrinology , medicine , follicle stimulating hormone , danazol , hormone , basal (medicine) , basal body temperature , menstrual cycle , gonadotropic cell , biology , chemistry , endometriosis , insulin
Summary In each of six healthy, normally menstruating women, serum oestradiol, progesterone, basal and post luteinizing hormone releasing hormone (LHRH) gonadotrophin measurements were made during the luteal phase of a normal cycle and in a subsequent cycle in which 800 mg of danazol was given daily from the fifth day after the presumptive date of ovulation. No differences in the serum oestradiol, progesterone, or basal gonadotrophin levels were detected, but there was a selective impairment of the follicle stimulating hormone response to LHRH. The implications of these findings are discussed.