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BLOOD COAGULATION, FIBRINOLYSIS AND PLASMA PROTEINS IN WOMEN WITH NORMAL AND WITH EXCESSIVE MENSTRUAL BLOOD LOSS
Author(s) -
Hahn L.,
Cederblad G.,
Rybo G.,
Pehrsson NG.,
KorsanBengtsen K.
Publication year - 1976
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1976.tb00784.x
Subject(s) - fibrinolysis , fibrinogen , medicine , antithrombin , endocrinology , antifibrinolytic , fibrin , orosomucoid , coagulation , albumin , menstrual cycle , ceruloplasmin , tranexamic acid , immunology , chemistry , heparin , surgery , biochemistry , glycoprotein , hormone , blood loss
Summary A group of women with excessive menstrual blood loss (menorrhagia) without any known local or general underlying disease was studied and compared to a group of women with normal menstrual blood loss. Blood coagulation, platelet function and fibrinolysis as well as a variety of plasma proteins were analyzed on six occasions during one menstrual cycle. Womenwith menorrhagia were found to have a slightly higher concentration of fibrinogen–fibrin degradation products, a higher factor V and VIII activity, higher antithrombin III, alpha 1 ‐antitrypsin concentrations and higher antifibrinolytic activity than the normal women. The concentration of albumin, beta IE ‐globulin, orosomucoid, ceruloplasmin and IgG were lower in women with menorrhagia than in normals. The capillary fragility did not differ significantly between the groups. The observed differences in clotting factors between the groups could not have caused the differences in blood losses.