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SEQUENTIAL STUDIES ON COMPONENTS OF THE HAEMOSTATIC MECHANISM IN PREGNANCY WITH PARTICULAR REFERENCE TO THE DEVELOPMENT OF PRE‐ECLAMPSIA
Author(s) -
Condie R. G.,
Ogston D.
Publication year - 1976
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1976.tb00779.x
Subject(s) - eclampsia , pregnancy , fibrinogen , medicine , obstetrics , mechanism (biology) , biology , genetics , philosophy , epistemology
Summary Components of the haemostatic mechanism were studied at intervals in 60 primigravidae over the course of pregnancy and the puerperium; 12 of these developed pre‐eclampsia. During pregnancy there was a fall in fibrinolytic activity and fibrinolytic capacity and a rise in fibrinogen, FR‐antigen, α 1 ‐antitrypsin and α 2 ‐macroglobulin. The women who subsequently developed pre‐eclampsia could not be identified on the basis of these measurements. Following delivery there was a more rapid return of fibrinolytic activity and capacity towards normal in the women who had not had pre‐eclampsia. The urinary FR‐antigen level was higher in the women with pre‐eclampsia.