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PLASMA LEVELS OF PREGNANCY–SPECIFIC β 1 –GLYCOPROTEIN IN NORMAL PREGNANCY
Author(s) -
Towler C. M.,
Horne C. H. W.,
Jandial V.,
Campbell Doris M.,
MacGillivray I.
Publication year - 1976
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1976.tb00743.x
Subject(s) - human placental lactogen , placental lactogen , pregnancy , gestation , trophoblast , glycoprotein , medicine , obstetrics , early pregnancy factor , endocrinology , biology , andrology , placenta , fetus , biochemistry , genetics
Summary Pregnancy‐specific β 1 –glycoprotein (PSβG) is a major product of the trophoblast which has only recently been identified. Like human placental lactogen, the concentration of PSβG in maternal blood rises throughout pregnancy until about 34 weeks, thereafter tending to remain constant until term, with only a small day‐to‐day variation in individuals. The circulating maternal levels of PSβG between 34 weeks and term are about 200 μg/ml, 20 to 30 times greater than the levels of placental lactogen, thus allowing detection and measurement of PSβG by relatively simple techniques. The levels of PSβG are above the normal range in the majority of twin pregnancies. It is suggested that PSβG measurements may be useful in assessing placental function and may help in the detection of multiple pregnancies at an early stage of gestation.