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THE EFFECTS OF NARCOTICS ON FETAL ACID BASE STATUS
Author(s) -
Chang A.,
Wood C.,
Humphrey M.,
Gilbert M.,
Wagstaff C.
Publication year - 1976
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1976.tb00731.x
Subject(s) - nalorphine , pethidine , fetus , morphine , heroin , dose , anesthesia , medicine , pregnancy , pharmacology , opioid , drug , biology , analgesic , (+) naloxone , receptor , genetics
Summary This paper reports two randomized control trials on the effects of nalorphine, pethidine, morphine and heroin on fetal and maternal acid base status. The drugs decreased pH and increased pCO 2 in the mother, and decreased pH and base excess in the fetus. The changes in the fetus were independent of the changes in the mother. In equivalent dosages, nalorphine increased maternal pCO 2 more than pethidine and morphine. The effects of heroin were found to be greater than that of other drugs, and we suggest that heroin should be avoided where the fetus is already at risk.