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STUDIES ON COAGULATION AND FIBRINOLYSLS IN BLOOD FROM PUERPERAL WOMEN WITH AND WITHOUT OESTROGEN TREATMENT
Author(s) -
Gjønnáss Halvard,
Fagerhol Magne K.,
Stormorken Helge
Publication year - 1975
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1975.tb02214.x
Subject(s) - antithrombin , coagulation , fibrinogen , antifibrinolytic , medicine , endocrinology , lactation , platelet , fibrinolysis , pregnancy , postpartum period , heparin , surgery , biology , blood loss , tranexamic acid , genetics
Summary Coagulation and fibrinolytic studies were made on 25 women who had a normal puerperium and breast fed their babies and on 32 otherwise healthy women who had lactation suppressed by diethylstilboestrol. In the untreated patients the fibrinogen, Factors VIII and IX, platelet count, and antifibrinolytic activity increased, and the levels of Factors II, VII, and X and of plasminogen and plasminogen proactivator decreased. The incidence of cold activation of Factor VII decreased slowly from the 5th postpartum day onwards. The concentration of antithrombin TI1 which was depressed in pregnancy, increased in the puerperiuin and was the only observed change that counteracted an increased coagulation potential. Oestrogen treatment produced further increases of Factors II, VII, and X, platelet count, and the cold activation of Factor VII while it decreased the concentration of antithrombin III. These changes favoured coagulation but were possibly to some degree counterbalanced by an increased concentration of plasminogen and decreased antifibrinolytic activity.