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THE RENAL CLEARANCE OF OESTRIOL IN LATE HUMAN PREGNANCY
Author(s) -
Swapp Garden H.,
Masson Gorden M.,
Klopper Arnold I.
Publication year - 1975
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1975.tb02210.x
Subject(s) - probenecid , renal function , chemistry , pregnancy , endocrinology , medicine , inulin , estriol , kidney , chromatography , biochemistry , biology , hormone , genetics
Summary The renal clearance of unconjugated oestriol, oestriol glucosiduronate and oestriol sulphate by the kidney in late human pregnancy has been compared with simultaneous measurements of inulin clearance. The results for the fractions not bound to protein indicate that after glomerular filtration, unconjugated oestriol is completely reabsorbed, oestriol glucosiduronate is both filtered and excreted actively by the tubules, and that oestriol sulphate is filtered but not excreted or absorbed by the tubules; the administration of probenecid confirms these observations on tubular handling. The possibility of using endogenous oestriol sulphate as a means of measuring the glomerular filtration rate in pregnancy is suggested.