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ASSESSMENT OF PLACENTAL FUNCTION IN NORMAL AND PATHOLOGICAL PREGNANCIES BY ESTIMATION OF PLASMA OESTRADIOL LEVELS AFTER INJECTION OF DEHYDROEPIANDROSTERONE SULPHATE
Author(s) -
Korda A. R.,
Challis Janice J.,
Anderson Anne B. M.,
Turnbull A. C.
Publication year - 1975
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1975.tb00702.x
Subject(s) - dehydroepiandrosterone , medicine , pathological , endocrine system , endocrinology , fetus , proteinuria , dehydroepiandrosterone sulfate , fetal death , placenta , pregnancy , hormone , androgen , biology , kidney , genetics
Summary A test of placental function was assessed by measurement of plasma oestradiol levels in 32 patients after intravenous injection of 50 mg dehydroepiandrosterone sulphate (DHAS). Every pregnant patient showed a rise in plasma oestradiol after DHAS; two puerperal patients showed no rise. It was not possible to distinguish the variable response in normal pregnancy from that in patients with severe hypertension and proteinuria or with retarded intrauterine fetal growth. The test was of no value in one hypertensive patient as a predictor of fetal death eight da ys later or, in another, to confirm fetal death of two days duration. Our results do not suggest that this test is a useful addition to currently available tests of placental endocrine function.