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PATHOLOGICAL MECHANISMS TO EXPLAIN SOME CASES OF AMENORRHOEA WITHOUT ORGANIC DISEASE
Author(s) -
Shaw R. W.,
Butt W. R.,
London D. R.
Publication year - 1975
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1975.tb00645.x
Subject(s) - pathological , disease , organic disease , medicine , pathology
Summary A test is described to define the site of the lesion causing amenorrhoea in women of child‐bearing age who have normal ovaries and a normal response to luteinizing hormone‐releasing hormone (LH‐RH). Patients able to produce a release of LH following the administration of 1 mg. of oestradiol benzoate (EB) have normal hypothalamic function and thus the site of the defect must lie more centrally in the brain. Patients unable to show these LH surges have either a primary or econdary abnormality affecting their hypothalamic oestrogen “receptor” mechanism or their ability to produce LH‐RH.