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ELECTROENCEPHALOGRAPHIC CHANGES AFTER INTRAAMNIOTIC PROSTAGLANDIN F 2α AND HYPERTONIC SALINE
Author(s) -
Shearman R. P.,
Lyneham R. C.,
Walsh J. C.,
Itzkowic D.,
Shutt D. A.
Publication year - 1975
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1975.tb00641.x
Subject(s) - prostaglandin f2alpha , hypertonic saline , medicine , saline , anesthesia , tonicity , electroencephalography , amniotic fluid , therapeutic abortion , abortion , pregnancy , prostaglandin , obstetrics , fetus , biology , psychiatry , genetics
Summary Six major convulsions have been seen among 555 patients who had therapeutic second trimester abortion by intra‐amniotic prostaglandin F 2α (PGF 2α ). Five of 21 patients receiving intra‐amniotic hypertonic saline and 5 of 16 patients receiving PGF 2α showed abnormalities in electroencephalograms after treatment. These changes were relatively minor in all saline patients and in three receiving PGF 2α , but two patients receiving PGF 2α showed epileptiform spike activity after infusion. There was no correlation between the electroencephalographic (EEG) changes and peripheral venous levels of PGF 2α or its metabolite, 13, 14 dihydro‐15 keto PGF 2α (15 keto‐h 2 ‐F 2α ).