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BLOOD COAGULATION PROFlLE IN INDIAN PATIENTS WITH PRE‐ECLAMPSIA AND ECLAMPSIA
Author(s) -
Dube B.,
Bhattacharya Sulekha,
Kanta Dube Rama
Publication year - 1975
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1975.tb00560.x
Subject(s) - eclampsia , medicine , disseminated intravascular coagulation , coagulation , pregnancy , fibrinogen , preeclampsia , obstetrics , biology , genetics
Summary Twelve Indian patients with pre‐eclampsia, 15 with eclampsia and 15 with normal pregnancy in the third trimester were investigated. A systemic bleeding diathesis was encountered in two patients with eclampsia and in none with pre‐eclampsia; two patients with pre‐eclampsia, however, had excessive uterine haemorrhage. Coagulation studies showed statistically significant prolongation of thrombin time, elevation of serum fibrinogen degradation products (FDP) and hypofibrino‐ genaemia in patients with pre‐eclampsia as well as eclampsia. In patients with eclampsia, significant thrombocytopenia also occurred. Euglobulin lysis time showed no significant change in patients with pre‐eclampsia and eclampsia. There was no significant difference in the coagulation profile between patients with eclampsia and pre‐eclampsia, except for more hypofibrinogenaemia in the former. The laboratory findings suggest the occurrence of intravascular coagulation