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EFFECT OF COPPER ON GROWTH OF HUMAN CERVICAL EPITHELIAL CELLS IN TISSUE CULTURE
Author(s) -
Hounsell P. G.,
Hawkins D. F.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00547.x
Subject(s) - copper , epithelium , explant culture , tissue culture , mitosis , cell culture , uterus , biology , andrology , chemistry , microbiology and biotechnology , pathology , in vitro , medicine , endocrinology , biochemistry , genetics , organic chemistry
Summary Copper sulphate in concentrations of 4×10 −4 M or more completely prevents outgrowth of explants of human cervical squamous epithelium in monolayer tissue culture. Concentrations of 3×10 −5 M copper or more reduce the rate at which cells in the cultures enter the mitotic phase. These findings are discussed in relation to the use of copper‐releasing intrauterine contraceptive devices.