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AN ASSESSMENT OF URINARY AND PLASMA STEROID ESTIMATIONS FOR MONITORING TREATMENT OF ANOVULATION WITH GONADOTROPHINS
Author(s) -
Black W. P.,
Coutts J. R. T.,
Dodson Kay S.,
Rao L. G. S.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00538.x
Subject(s) - pregnanediol , ovulation , menotropins , anovulation , medicine , human chorionic gonadotropin , urinary system , endocrinology , stimulation , ovulation induction , gonadotropin , infertility , gynecology , pregnancy , biology , hormone , insulin resistance , polycystic ovary , insulin , genetics
Summary Total urinary oestrogens (UE), plasma oestradiol‐17β (PE 2 ), plasma progesterone and urinary pregnanediol values were estimated during 28 cycles of treatment with human menopausal gonadotrophins (HMG) and human chorionic gonadotrophin (HCG) in seven patients with primary or secondary amenorrhoea who complained of infertility. Ovulation occurred in 23 courses of treatment and three patients became pregnant. PE 2 estimations gave a more accurate day to day assessment of the response of patients to treatment than UE values. Monitoring of treatment with PE 2 values should reduce any tendency to overstimulation with HMG and allow more accurate timing of the first HCG injection which is critical for a successful ovulatory response. The first HCG dose is an effective stimulus to ovulation when administered on the day of the UE peak which is the day after the PE 2 peak. The first HCG dose appeared to be an ineffective stimulus to ovulation if given subsequent to this time or more than two days after the last HMG stimulation.