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SEROMUCOID IN SERUM IN BENIGN AND MALIGNANT GYNAECOLOGICAL DISORDERS
Author(s) -
Randle G. H.,
Good W.,
Cumberbatch K. N.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00501.x
Subject(s) - medicine , lesion , orosomucoid , cancer , carcinoma , gastroenterology , pathology , glycoprotein , microbiology and biotechnology , biology
Summary The serum levels of seromucoid were examined in patients with a wide variety of benign and malignant gynaecological disorders. Seromucoid was unchanged from normal in most benign conditions, but it was raised in pelvic infection and tended to be low in infertility. Serum seromucoid was unchanged in patients with carcinoma in situ, but was increased substantially above normal with invasive cancer. The level of serum seromucoid in patients with cancer was related to the severity of the clinical lesion and returned to normal when the lesion was successfully treated. Cases of recurrent carcinoma had highly elevated serum seromucoid levels. The measurement of serum seromucoid levels may be a useful means of assessing the severity of cancer and monitoring the effectiveness of its treatment.