Premium
THE EFFECT OF FRUSEMIDE ON URIC ACID LEVELS IN MATERNAL BLOOD, FETAL BLOOD AND AMNIOTIC FLUID
Author(s) -
Carswell W.,
Semple P. F.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00499.x
Subject(s) - uric acid , amniotic fluid , fetus , medicine , endocrinology , eclampsia , pregnancy , biology , genetics
Summary Concurrent measurements of uric acid levels in maternal serum, fetal serum and amniotic fluid were made in 52 patients. The patients with pre‐eclampsia who were not on frusemide had higher uric acid levels in all fluids studied than did the untreated controls and frusemide increased the uric acid levels further in both types of patient. The potentially harmful effect on the fetus of high uric acid levels induced by frusemide should be considered. Raised levels of uric acid in amniotic fluid may invalidate the use of this measurement as an index of fetal maturity in patients who have pre‐eclampsia or who are on diuretics.