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THE SELECTIVE UPTAKE OF TAMOXIFEN BY HUMAN UTERINE TISSUE
Author(s) -
Fromson J. M.,
Sharp D. S.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00468.x
Subject(s) - tamoxifen , endometrium , dysfunctional uterine bleeding , uterus , menstrual cycle , hysterectomy , corpus luteum , endocrinology , medicine , menstruation , chemistry , breast cancer , ovary , hormone , cancer , pathology
Summary A series of patients who were suffering from dysfunctional uterine bleeding (menorrhagia) were dosed with [ 14 C] tamoxifen prior to hysterectomy being performed. The proportion of the labelled dose which became bound to the various tissues of the uterus at different stages of the menstrual cycle was investigated. There was no apparent variation in the uptake of the compound during the menstrual cycle. However, it was found that the levels of radioactivity in the uterine tissues examined were higher than those found in the serum and that the proportion of radioactivity representing unchanged drug was two to three times that found in the serum. It appeared that tamoxifen had a definite affinity for the endometrium and that there was also some selective uptake by the corpus luteum.