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THE EFFECT OF PREGNANCY ON INTRAVENOUS GLUCOSE TOLERANCE
Author(s) -
Fisher Peter M.,
Hamilton Pamela M.,
Sutherland Hamish W.,
Stowers John M.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00461.x
Subject(s) - pregnancy , gestation , medicine , plasma glucose , significant difference , endocrinology , diabetes mellitus , glucose tolerance test , third trimester , obstetrics , biology , insulin resistance , genetics
Summary Eleven normal pregnant women selected specifically to avoid the stigmata of potential diabetes, had serial, rapid 25 g. intravenous glucose tolerance tests done at 11 to 13, 25 to 27, and 37 to 39 week's gestation. The results expressed as increment indices and k values showed a significant decrease in glucose tolerance between the second and third trimesters. The difference in the increment indices, between the first and second trimesters was also significant There was no significant difference in the mean fasting venous plasma glucose levels between the three stages of pregnancy studied. It is concluded that intravenous glucose tolerance decreases with advancing gestation.