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GLUCOSE‐INSULIN INTERACTION AND THE MODULATION OF HUMAN PLACENTAL LACTOGEN (HPL) SECRETION DURING PREGNANCY
Author(s) -
Gaspard U.,
Sandront H.,
Luyckx A.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00446.x
Subject(s) - endocrinology , medicine , radioimmunoassay , human placental lactogen , insulin , placental lactogen , pregnancy , biology , fetus , placenta , genetics
Summary In order to define metabolic factors which control human placental lactogen (HPL) secretion two types of experiment have been conducted: (a) hypoglycaemia was induced by intravenously‐injected insulin in 21 normal women in late pregnancy; and (b) a sustained hyperglycaemia was obtained by glucose infusion in six normal women in late pregnancy. Serum HPL was determined using an immunosorbent antibody radioimmunoassay procedure. Blood glucose was estimated in both experiments and plasma immunoreactive insulin in the second. The results show an inverse relationship between blood glucose and serum HPL concentrations. Hyperglycaemia caused the HPL level to fall and conversely insulin‐induced hypoglycaemia caused it to rise. Moreover, declining blood glucose levels after the cessation of a glucose infusion were accompanied by an increase in HPL comparable to that seen during frank hypoglycaemia.