Premium
PLASMA OESTRADIOL RESPONSE TO SYNTHETIC FOLLICLE STIMULATING HORMONE/LUTEINIZING HORMONE RELEASING HORMONE IN PATIENTS WITH SECONDARY AMENORRHOEA
Author(s) -
Katz M.,
Carr P. J.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00382.x
Subject(s) - luteinizing hormone , follicle stimulating hormone , medicine , endocrinology , hormone , basal (medicine) , gonadotropic cell , biology , insulin
Summary Plasma oestradiol showed a two‐ to three‐fold rise above the mean basal level by six hours after a single intravenous injection of synthetic Luteinizing Hormone and Follicle Stimulating Hormone Releasing Hormone (LH‐RH/FSH‐RH) in nine out of twelve patients with secondary amenorrhoea. Of the remaining three patients, two had persistently high basal plasma gonadotrophins in keeping with a diagnosis of premature menopause and one patient had secondary amenorrhoea of seven years' duration. It is suggested that a six‐hour plasma oestradiol estimate be used as the endpoint of the LH‐RH/FSH‐RH test in order to assess the pituitary‐ovarian axis. If a less than two‐fold increase in plasma oestradiol is found, pituitary reserve can be more intensively studied by assaying plasma follicle stimulating hormone (FSH) and luteinizing hormone (LH).