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EFFECT OF A SYSTEMICALLY ADMINISTERED PROGESTOGEN ON HISTOPATHOLOGY OF ENDOMETRIAL CARCINOMA
Author(s) -
John A. Howard,
Cornes J. S.,
Jackson Warwick D.,
Bye Patrick
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00381.x
Subject(s) - progestogen , curettage , medicine , carcinoma , histopathology , hysterectomy , estrogen , gynecology , oncology , pathology
Summary In twenty patients, Stage I endometrial carcinoma was diagnosed by curettage and treated with gestonorone caproate given systemically, prior to hysterectomy. The histological appearances of the tumours before and after treatment were compared and were related to the total dose of progestogen given. In general, regression of the tumour was noted together with increase in differentiation, particularly of tumours initially showing some degree of differentiation. The future of progestogens in the treatment of endometrial carcinoma is discussed.