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AMNIOTIC FLUID ALPHA‐FETOPROTEIN IN THE ANTENATAL DIAGNOSIS OF NEURAL TUBE DEFECTS
Author(s) -
Nevin N. C.,
Thompson W.,
Nesbitt S.
Publication year - 1974
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1974.tb00376.x
Subject(s) - neural tube , amniotic fluid , fetus , alpha fetoprotein , obstetrics , medicine , neural tube defect , tube (container) , alpha (finance) , pregnancy , biology , surgery , embryo , materials science , construct validity , genetics , hepatocellular carcinoma , patient satisfaction , composite material , microbiology and biotechnology
Summary Alpha‐fetoprotein (AFP) has been estimated in 358 specimens of amniotic fluid from 221 pregnancies terminating in the delivery of a normal infant and in the amniotic fluid from 21 pregnancies in which the fetus turned out to have a neural tube defect. When the fetus had a neural tube defect, AFP levels before 36 weeks were raised above the 95th centile of normal controls with the exception of one patient in whom the fetus had a closed neural tube defect.