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INDUCTION OF HEPATIC ENZYMES DURING NORMAL HUMAN PREGNANCY
Author(s) -
Davis M.,
Simmons C. J.,
Dordoni B.,
Maxwell J. D.,
Williams Roger
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb16051.x
Subject(s) - enzyme inducer , pregnancy , enzyme , urinary system , microsome , endocrinology , medicine , enzyme assay , stimulation , liver enzyme , chemistry , biology , biochemistry , genetics
Summary Stimulation of hepatic microsomal enzyme activity, a process known as enzyme induction, occurs in response to high levels of progesterones in animals. The urinary output of D‐glucaric acid, which is an indirect measure of hepatic microsomal enzyme activity, has been measured in 142 healthy women at different stages of pregnancy. Urinary D‐glucaric acid output rose progressively from the 12th week until delivery, with a gradual fall to normal levels by the 6th week post partum. Twenty‐five women who had been taking oral contraceptives for at least a year had normal outputs of D‐glucaric acid. The possible significance of enzyme induction in pregnancy is discussed.