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COMPARISON OF INTRAVENOUS PROSTAGLANDINS F 2α AND E 2 , WITH INTRAVENOUS OXYTOCIN IN THE INDUCTION OF LABOUR
Author(s) -
Naismith William C. M. K.,
Barr Wallace,
Macvicar J.
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb15975.x
Subject(s) - oxytocin , medicine , prostaglandin f2alpha , cervix , apgar score , cervical dilatation , anesthesia , bishop score , vaginal delivery , prostaglandin , obstetrics , pregnancy , birth weight , cancer , biology , genetics
Summary Three groups of primigravidae, matched for age, height, weight, maturity and inducibility score were studied in order to compare the effectiveness as induction agents of intravenously administered prostaglandin F, (PGF,), prostaglandin E, (PGE) and oxytocin (Syntocinon) in escalating dosage. In all cases, amniotomy was postponed until labour had become established and, if this did not occur within 12 hours, the drug was discontinued. Oxytocin in the dosage employed was the most effective of the three drugs tested. Of the 20 patients given oxytocin, 19 progressed to vaginal delivery, the mean infusion‐delivery interval being 10 hours 8 minutes. Of the 10 patients given PGE, and the 10 patients given PGF, 5 showed no dilatation of the cervix within 12 hours, and the remaining 15 had a mean infusion‐delivery interval of 13 hours and 23 minutes. Side effects were not severe with any of the drugs employed, and Apgar scores of the newborn showed no significant difference in the groups studied.