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A COMPARATIVE STUDY OF DIAMINE OXIDASE IN AMNIOTIC FLUID AND SERUM IN NORMAL PREGNANCY AND IN PREGNANCY COMPLICATED BY RHESUS ISO‐IMMUNIZATION
Author(s) -
Ward Humphry,
Whyley G. A.,
Millar M. D.
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb15974.x
Subject(s) - amniotic fluid , diamine oxidase , pregnancy , medicine , fetus , obstetrics , andrology , significant difference , positive correlation , physiology , endocrinology , chemistry , biology , enzyme , biochemistry , genetics
Summary Diamine oxidase (DAO) was estimated in the amniotic fluid and serum of 65 women, 28 of whom had rhesus iso‐immunization. There was a wide scatter of values throughout normal pregnancy. Initially, DAO values in amniotic fluid were lower than in serum, but later in pregnancy the pattern was reversed. The DAO level in amniotic fluid did not correlate with the severity of the rhesus iso‐immunization but the mean level in severe disease when the baby survived was significantly higher than that found in patients with unaffected pregnancies. Fetal outcome also made a significant difference to amniotic fluid DAO levels. The amniotic fluid/serum DAO ratio showed a significantly higher value in the severely affected pregnancies than in those unaffected by rhesus iso‐immunization. A correlation existed between the ratio and the optical density difference (A) at 450 mp. It is suggested that the amniotic fluid/serum DAO ratio taken in conjunction with the A 450 mp peak might provide a guide to the ultimate outcome for the fetus.