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CONTINUOUS EXTRA‐AMNIOTIC PROSTAGLANDIN E 2 FOR THERAPEUTIC TERMINATION AND THE EFFECTIVENESS O VARIOUS INFUSION RATES AND DOSAGES
Author(s) -
Midwinter Audrey,
Shepherd Angela,
Bowen Michael
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb11212.x
Subject(s) - dose , medicine , prostaglandin e , prostaglandin , gestation , prostaglandin e1 , anesthesia , abortion , pregnancy , obstetrics , gynecology , endocrinology , biology , genetics
Summary Continuous extra‐amniotic prostaglandin E 2 (PGE 2 ) was given to 91 healthy women to terminate pregnancies of from 10–20 weeks gestation. One patient failed to abort. Of 68 patients given doses of 66–5 to 133–5μg. of PGE 2 per hour, 61 aborted within 36 hours. Using 46.5μg. of PGE 2 per hour the mean induction‐abortion interval was increased and only 13 of 20 patients aborted within 36 hours. Persistent side‐effects limited treatment with doses of 333.5μg. of PGE 2 per hour. Less PGE 2 was used and there were practical advantages in giving 66.5μg. per hour.