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URINARY OESTRIOL IN PREGNANCY, DAILY FLUCTUATION, AND CORRELATION WITH FETAL GROWTH
Author(s) -
Bergsjøs Per,
Bakke Trygve,
Salamonsen Lois A.,
Støsa Karl F.,
Thorsen Thor
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb11196.x
Subject(s) - percentile , pregnancy , medicine , obstetrics , urinary system , fetus , fetal growth , growth retardation , excretion , endocrinology , biology , mathematics , statistics , genetics
Summary Urinary oestriol output in 214 series of three consecutive 24‐hour periods during late pregnancy showed large day‐to‐day fluctuations. The clinical correlations have been based on the mean excretion value of each three‐day series. From 30 weeks of pregnancy onwards there was a highly significant difference in the oestriol output between mothers who had normal‐sized babies (birthweight above the 25th percentile) and those who had small‐for‐dates babies (birthweight below the 10th percentile). Serial oestriol determinations also showed that in pregnancies with growth‐retarded fetuses the levels were persistently low, or falling, while in pregnancies with normal‐sized fetuses the levels rose, often sharply. The shape of the curves was more important than the actual values in predicting the outcome with regard to the birthweight of the baby.