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INTRAVASCULAR COAGULATION DURING PREGNANCY AND THE PUERPERIUM
Author(s) -
Hyde Elisabeth,
Joyce David,
Gurewich Victor,
Flute Peter T.,
Barrera Samuel
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb02980.x
Subject(s) - medicine , fibrinogen , fibrinolysis , pregnancy , obstetrics , miscarriage , coagulation , gynecology , postpartum period , fibrin , immunology , genetics , biology
Summary The presence of activated coagulation and fibrinolysis during pregnancy and the early puerperium was detected by measurement of fibrin monomer, fibrin degradation products (f.d.p.) and fibrinogen/fibrin degradation products (FDP) in 285 women during normal pregnancy, 57 women with a previous history of miscarriage, 35 women with pre–eclampsia, 253 women during the first week post partum and 15 women with postpartum complications including thromboembolic disease, infection and haemorrhage. The effects of age, parity, smoking, bacteriuria, ABO blood group, type of delivery, and postpartum administration of oestrogen for suppression of lactation were analyzed. Our findings indicated that activated coagulation and fibrinolysis are common occurrences during pregnancy and the puerperium. Primigravidae and women with pre–eclampsia, postpartum complications and a history of miscarriage had a significantly higher incidence and level of these fibrinogen derivatives than women with uncomplicated pregnancies and deliveries.