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SENSITIVITY OF TRICHOMONAS VAGINALIS TO CHEMOTHERAPEUTIC AGENTS
Author(s) -
Paredes F. R.,
Hawkins D. F.
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb02138.x
Subject(s) - trichomonas vaginalis , natamycin , metronidazole , trichomonas , trichomoniasis , microbiology and biotechnology , trichomonas vaginitis , chemistry , antibiotics , in vitro , nystatin , biology , pharmacology , medicine , food science , gynecology , biochemistry
Summary The trichomonacidal activities in vitro of six drugs were compared using strains of Trichomonas vaginalis freshly isolated from patients. Metronidazole, nitrimidazine and nifuratel were all active in concentrations of the order of 1 μg./ml. Amphotericin B, a mixture of polyethylene glycols, and natamycin was much less active. Three out of ten strains of Trichomonas vaginalis were resistant to 1 mg./ml. of natamycin. Since nitrimidazine and nifuratel are less therapeutically effective than metronidazole, it is possible that some substance in vaginal tissues or secretion tends to protect the organisms against these drugs.