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INFLUENCE OF THE PROGESTOGENIC COMPONENT OF ORAL CONTRACEPTIVES ON TRYPTOPHAN METABOLISM
Author(s) -
Rose D. P.,
Adams P. W.,
Strong R.
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb02137.x
Subject(s) - mestranol , xanthurenic acid , norethisterone , medicine , endocrinology , excretion , lynestrenol , urine , tryptophan , chemistry , population , biochemistry , research methodology , amino acid , family planning , environmental health
Summary Patients taking 0.05 mg. of ethinyl oestradiol and 2.5 mg. of lynestrenol (Minilyn) showed, at most, only a mild rise in xanthurenic acid excretion in urine, while very marked rises in xanthurenic acid secretion were found in patients taking 0.05 mg. of ethinyl oestradiol with 1 mg. of norethisterone (Minovlar), or 3 mg. of norethisterone (Gynovlar) or 1 mg. of ethynodiol diacetate (Ovulen 50). Patients taking 0.05 mg. of mestranol with 1 mg. of norethisterone (Norinyl 1) showed a smaller rise in the urinary excretion of kynurenine or 3‐hydroxykynurenine than did those taking Minovlar.