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EFFECT OF DYDROGESTERONE (DUPHASTON) ON HAEMOSTASIS AND LIVER FUNCTION
Author(s) -
Vermylen J.,
Verstraete M.,
Brosens I.
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb02136.x
Subject(s) - dydrogesterone , partial thromboplastin time , medicine , prothrombin time , liver function , platelet , factor vii , platelet adhesiveness , endocrinology , fibrinogen , alkaline phosphatase , bilirubin , chemistry , coagulation , platelet aggregation , biochemistry , estrogen , enzyme
Summary Measurements of blood coagulability and liver function parameters were made on alternate weeks in 14 young unmarried female volunteers for two months before and for three months during fortnightly intramuscular injections of 100 mg. of dydrogesterone (Duphaston Depot). No difference, significant at the 5 per cent level, was found for the following: fibrinogen, the prothrombin‐proconvertin complex, factor VII, factor X, partial thromboplastin time with or without previous kaolin activation, euglobulin lytic activity, antiplasmin, platelet count, collagen induced platelet aggregation or platelet adhesiveness to a glass bead column. A small but statistically significant reduction of factor VIII and plasminogen was noted in association with dydrogesterone administration. No significant difference of serum glutamic pyruvic or serum glutamic oxalacetic transaminases levels or of thymol and zinc sulphate turbidity tests was observed between the samples taken before and during dydrogesterone administration. A slight but statistically significant reduction of alkaline phosphatase and of total bilirubin was, however, noted.