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FREE AMINO ACID COMPOSITION OF HUMAN AMNIOTIC FLUID AT TERM
Author(s) -
Cockburn F.,
Giles M.,
Robins S. P.,
Forfar J. O.
Publication year - 1973
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1973.tb02122.x
Subject(s) - amniotic fluid , urine , fetus , medicine , amino acid , endocrinology , fetal circulation , amniotic sac , pregnancy , chemistry , biology , placenta , biochemistry , genetics
Summary Patterns of free amino acid concentrations in maternal venous plasma, umbilical arterial plasma, fetal urine, amniotic fluid and neonatal urine from eight infants delivered at term by elective Caesarean section before the onset of labour were determined. Concentrations of amino acids were in general greater in fetal plasma than in maternal plasma, amniotic fluid, fetal urine and neonatal urine. There was little correlation between amniotic fluid amino acid composition and the composition of fetal urine, fetal plasma or maternal plasma. Urine excreted during the first 24 hours after birth had a higher osmolality and greater amino acid concentrations than fetal urine in the bladder at the time of delivery. When compared with the urine in the bladder of fetuses delivered at 15 to 20 weeks, fetal urine at term has a lower osmolality and a different amino acid composition which is partially explained by reduced fetal plasma amino acid concentrations in later pregnancy and by alterations in the endogenous renal clearance of some amino acids.