Premium
THE RELATIONSHIP OF THE POSTPARTUM RISE IN SEROMUCOID TO PRIMIGRAVID PLACENTAL WEIGHT
Author(s) -
Good W.,
Hancock K. W.,
Macdonald H. N.
Publication year - 1972
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1972.tb15745.x
Subject(s) - trophoblast , glycoprotein , antigen , histocompatibility , immune system , pregnancy , immunology , antibody , orosomucoid , medicine , placenta , andrology , biology , human leukocyte antigen , fetus , biochemistry , genetics
Summary The postpartum rise in seromucoid, which is an heterogenous acid‐soluble glycoprotein sub‐fraction, is related to placentalweight in primigravidae but not in multigravidae. This observation supports the view that primigravidae, who have had no previous exposure to paternal histocompatibility antigens, depend on glycoprotein to mask the trophoblast from the cellular immune response. With previous exposure to paternal histocompatibility antigens, as in multigravidae, the maternal antibodies so formed may coat the trophoblast and thus reduce the need for a covering of nonspecific glycoprotein.