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THE CIRCULATING LEVELS OF OXYTOCIN FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION OF SYNTOMETRINE
Author(s) -
Gibbens D.,
Boyd N. R. H.,
Crocker S.,
Baumber S.,
Chard T.
Publication year - 1972
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1972.tb14215.x
Subject(s) - oxytocin , intramuscular injection , ergometrine , medicine , anesthesia , endocrinology
Summary Using a radioinimunoassay for oxytocin, circulating levels of the hormone were measured following intravenous and intramuscular administration of Syntometrine. After intramuscular injection oxytocin appeared in the circulation in as little as 30 seconds and continued to be detectable at levels around 25 pg. per ml. for up to 60 minutes. After intravenous injection there was a rapid rise to a peak of 530 pg. per ml. at one minute. The subsequent decay showed a bi‐exponential pattern, and yielded an average half‐life of 3 minutes for the initial rapid phase of disappearance. Following subcutaneous injection of Syntometrine, circulating oxytocin was found in only one of the two cases studied. After intravenous ergometrine, there was no detectable rise in oxytocin levels.