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SYSTEMIC FIBRINOLYSIS DURING AND FOLLOWING ELECTIVE CAESAREAN SECTION AND GYNAECOLOGICAL OPERATIONS
Author(s) -
Woodfield D. G.,
Cole Susan K.,
Allan A. G. E.,
Cash John D.
Publication year - 1972
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1972.tb14197.x
Subject(s) - fibrinolysis , medicine , caesarean section , plasminogen activator , fibrinogen , obstetrics , hysterectomy , elective caesarean section , fibrin , tissue plasminogen activator , pregnancy , surgery , immunology , genetics , biology
Summary The changes in systemic plasminogen activator and serum fibrinogen‐fibrin degradation products (FDP) during and following elective Caesarean section have been studied in ten healthy pregnant women, and compared with the changes observed in ten age‐matched non‐pregnant women undergoing hysterectomy or salpingectomy. The Caesarean section patients showed a highly significant reduction in plasminogen activator response during operation. No significant difference was observed in the serum FDP responses. These results confirm the view that depression in the ability to mobilize plasminogen activator occurs in the later months of normal pregnancy. The clinical relationship of this to the development of uncompensated disseminated intravascular coagulation is discussed.