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RING CHROMOSOMES IN CARCINOMA IN SITU OF THE CERVIX AS EVIDENCE OF CLONAL GROWTH
Author(s) -
Spriggs A. I.,
Cowdell R. H.
Publication year - 1972
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1972.tb12930.x
Subject(s) - cervix , anaphase , clone (java method) , carcinoma in situ , pathology , biology , epithelium , ring chromosome , biopsy , carcinoma , chromosome , medicine , genetics , karyotype , cancer , dna , gene
Summary Two cases are described in which ring chromosomes were found in direct preparations of cervical epithelium showing presumptive precancerous states. Both showed “microcarcinoma”, though not in parts of the cervix from which samples for chromosomes were obtained. Similar ring chromsomes were seen in separate biopsy samples, demonstrating the extension of an abnormal clone. Failure of rings to separate at anaphase produced bridges visible in histological sections, and (in one case) in millipore preparations taken from the living cervix, and this confirmed the wide extent of spread of the neoplastic clone.