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THE EFFECTS OF A PROGESTOGEN, MEGESTROL ACETATE, ON CARBOHYDRATE AND LIPID METABOLISM
Author(s) -
Adams P. W.,
Wynn V.
Publication year - 1972
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1972.tb12911.x
Subject(s) - megestrol acetate , endocrinology , medicine , progestogen , triglyceride , megestrol , insulin , carbohydrate metabolism , cholesterol , carbohydrate , chemistry , hormone , cancer
Summary The metabolic effects of the administration of megestrol acetate 0.5 mg. daily have been studied in 31 women. In 26 women (Group A) studied before and after daily megestrol acetate administration there were no changes in plasma glucose, plasma insulin, blood pyruvate, serum triglyceride and serum cholesterol levels. Significant decreases in plasma glucose and plasma insulin and in blood pyruvate levels during oral and intravenous glucose tolerance tests were observed in 17 women (Group B) on substituting daily megestrol acetate for a combined oestrogen‐progestogen oral contraceptive (OC). In these women the fasting serum triglyceride and serum cholesterol levels also decreased. It is concluded that the daily administration of 0.5 mg. megestrol acetate does not alter carbohydrate or lipid metabolism. This may be an advantage over combined preparations. Offsetting this, however, was a fairly high incidence of side effects and in this small group, at least one method failure.