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HUMAN PLACENTAL LACTOGEN LEVELS IN PRE‐ECLAMPSIA
Author(s) -
Letchworth A. T.,
Chard T.
Publication year - 1972
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1972.tb12900.x
Subject(s) - eclampsia , human placental lactogen , medicine , placental lactogen , parity (physics) , prospective cohort study , endocrinology , clinical significance , fetus , obstetrics , pregnancy , placenta , biology , genetics , physics , particle physics
Summary A prospective study has been carried out on human placental lactogen (HPL) levels in pre‐eclampsia. The general conclusions were as follows: (1) the levels were lower than those in normal subjects; (2) the levels in mild pre‐eclampsia were lower than those in the moderate and severe cases; (3) the levels were lower in multipara than in primipara. The influence of severity and parity may partly explain the discrepancies encountered in earlier studies. Low levels of HPL were found in patients with fetal complications. However, since similar levels may be found in pre‐eclampsia without such complications, it was not possible to reach definite conclusions on the value of HPL determinations as a predictor of fetal well‐being. The results indicate the need for further investigation of the prognostic significance of HPL levels within sub‐groups of patients with pre‐eclampsia.