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FACTORS AFFECTING MYOMETRIAL ACTIVITY DURING PREGNANCY
Author(s) -
Brummer Hilary C.,
Collins William P.
Publication year - 1972
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1972.tb11875.x
Subject(s) - myometrium , pregnancy , medicine , gestation , endocrinology , peripheral , venous blood , uterus , uterine contraction , biology , genetics
Summary The relationship between the concentration of progesterone in peripheral venous plasma and in strips of myometrial tissue from 17 pregnant women has been studied. In addition, the sensitivity of 39 myometrial strips to various stimulants was examined by an in vitro technique. The responses were assessed in relation to the endogenous levels of progesterone, length of gestation, and parity of the subject. The results indicate that although the levels of progesterone in both peripheral venous plasma and myometrium rise during pregnancy there is no apparent correlation between the two. Myometrial sensitivity to Syntocinon and prostaglandins E 1 and E 2 is not dependent upon the level of progesterone in either the myometrium or peripheral venous plasma. Myometrial strips removed at term from multigravidae were more responsive to these drugs than those from primigravidae, but during the second trimester there was no statistically significant difference between the two.