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ACUTE INTERMITTENT PORPHYRIA AND PREGNANCY
Author(s) -
Hunter D. J. S.
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb01641.x
Subject(s) - pregnancy , medicine , acute intermittent porphyria , porphyria , falling (accident) , mortality rate , disease , obstetrics , pediatrics , surgery , psychiatry , genetics , biology
Summary The case of a woman with acute intermittent porphyria successfully completing her second pregnancy is described. Seventy‐two reported cases of acute intermittent porphyria complicated by pregnancy are reviewed. All but 5 of these patients suffered an attack during pregnancy. The mortality rate amongst primigravidae was 52 per cent, and in all cases 27 per cent. The severity of the disease during pregnancy is probably due to combination of the effect of pregnancy and injudicious administration of barbiturates. The mortality rate in pregnancy seems to be falling, probably due to an increasing awareness of the disease and its precipitating factors.