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CHOLINERGIC MECHANISMS IN THE HUMAN UTERUS
Author(s) -
Nakanishi H.,
Wood Carl
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb01635.x
Subject(s) - myometrium , cholinergic , muscarinic acetylcholine receptor , stimulation , endocrinology , medicine , uterus , carbachol , receptor , muscarinic acetylcholine receptor m2 , biology , chemistry
Summary The intrinsic cholinergic nerve supply of the human myometrium was studied by using electrical transmural stimulation and was found to be postganglionic and minimal. The pharmacological findings indicated that the human nonpregnant myometrium possessed sensitive cholinergic muscarinic receptors, but during pregnancy the sensitivity of the muscarinic receptors was markedly reduced. These results support our hypothesis that the human pregnant myometrium is protected from autonomic influence.