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AMNIOTIC FLUID TOTAL HYDROXYPROLINE AND INTRAUTERINE GROWTH
Author(s) -
Wharton B. A.,
Foulds J. W.,
Fraser I. D.,
Pennock C. A.
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00340.x
Subject(s) - hydroxyproline , amniotic fluid , creatinine , pregnancy , medicine , urinary system , urine , obstetrics , endocrinology , chemistry , physiology , biology , fetus , genetics
Summary In normal pregnancy amniotic fluid total hydroxyproline concentration rose to a peak around the 28th week, before falling steadily to term while creatinine concentration was at first constant and then rose rapidly to maximum values at term. The total hydroxyproline: creatinine ratio reached a zenith around 17 weeks and then fell rapidly. Total hydroxyproline concentrations tended to be lower in those pregnancies producing small‐for‐dates babies and those at particular risk of intrauterine growth retardation. The total hydroxyproline : creatinine ratio in the first urine passed by babies was a little higher than the amniotic fluid from the pregnancy concerned. After birth the urinary ratio rose rapidly. There is some evidence that changes in amniotic fluid total hydroxyproline and total hydroxyproline : creatinine ratio are related to intrauterine growth. Further information particularly from other animals is required. A determination of amniotic fluid total hydroxyproline may eventually prove to be clinically useful when considering induction of labour for pre‐eclampsia or maternal loss of weight towards term but a more intensive study during this period of pregnancy will be necessary before a firm, clinically useful conclusion can be made.